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<td bgcolor="#ffffff"><font color="#cc3366"> The DMT dreaming connection is very relevant. Pineal function is highest at 3 a.m., and so is dreaming activity. I propose, in the book, that DMT is a sort of spirit gland, with the highest level of precursors and enzymes of any organ in the body. Jace Callaway, in Finland, has proposed a role for pinoline, a beta-carboline, in boosting the effects of naturally released DMT during REM sleep. Along those lines, we *did* notice that many of our volunteers showed rapid eye movements during the peak of the DMT trance. So, it&undefined;s an extraordinarily relevant relationship.</font></td> |
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<td bgcolor="#ffffff"><font color="#cc3366">Other psychedelics have been studied since I stopped in 1995 ketamine, MDMA, and a little bit of ibogaine work that ended some years back. The only one with an eye on therapy was the ibogaine study, which stopped before it could attain full doses in their volunteers. There&undefined;s a psilocybin study in the works, maybe even starting, at the University of AZ in Tucson, which will give psilo to patients with severe obsessive compulsive disorder in an attempt to replicate and expand "field" reports of people with OCD getting at least temporarily better, after mushrooms. This study is modeled on a brain-chemistry, rather than a psychological model. That is, it&undefined;s not the trip, but the serotonin effects that are beneficial. But, it&undefined;s a start. There&undefined;s some talk of an LSD study at Harvard with the terminally ill. And there&undefined;s a group in Baltimore that may be close to starting an LSD study for people with serious drug abuse problems. </font></td> |
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<td bgcolor="#ffffff"><font color="#cc3366"> There&undefined;s lots in your questions. I think in the proper setting, DMT in ayahuasca can be helpful. Regarding the realities, I think this is hard to know. I propose, in my book, that DMT changes the receiving properties of consciousness, by changing the chemistry of the brain. And in doing so, allows consciousness access to realms, perhaps dark matter, or parallel universes, which exist right here and now, but are otherwise impossible to see. There is some merit in thinking along these lines, but I think at our current level of moral and ethical development, it&undefined;s probably more important to learn what we can from the states themselves, rather than speculating too awfully much on where they come from.</font></td> |
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<td bgcolor="#ffffff"><font color="#cc3366"> However, about Sasha&undefined;s compounds, they are quite interesting, and deserve more exploration. However, my feeling is that with the "old regulars," such as LSD, DMT, psilocybin, mescaline, we have such a wide range of possible responses from them, that we might be better served focusing on ones we know are safe before branching out into ones about which we know so litle.</font></td> |
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<td bgcolor="#ffffff"><font color="#cc3366"> I&undefined;ve raised some of the possiblities of endogenous DMT excess already, here and in the book. However, an endogenous defect isn&undefined;t something I&undefined;ve thought much about. Many of the drugs that are used to treat psychosis, block the same receptors that DMT activates, and if a "normal" person takes these "anti-psychotic" drugs, the world is very flat, dull, and lifeless. Perhaps people with depression have very low levels. That would be an interesting, and easy to do, study, although you&undefined;d need some pretty high tech measuring equipment.</font></td> |
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<td bgcolor="#ffffff"><font color="#cc3366"> All animals studied to date have DMT in their bodies: brain, liver, lung, spinal fluid, blood, urine. Many plants, too, as you know. In dark matter, the laws of physics are different than those of this universe, so all bets are off about "locality." There&undefined;s some stuff out there on "non-locality," but I plead ignorance of the field. By the way, the meditation link is interesting. Many people ask me, "Well, can&undefined;t you just get there with meditation?" And I usually answer, "Unlikely."</font></td> |
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